The epidemiology and natural history of gastroesophageal reflux disease is unclear.
The risk of esophageal adenocarcinoma is increased in patients with acid reflux, but the contribution of Barrett's lesions is unknown.
In this study, investigators from Denmark estimated the incidence of esophagitis lesions, as well as the risk of esophageal adenocarcinoma in patients with previously diagnosed esophagitis.
|The incidence of esophagitis lesions was 2.4 per 1000 person-years.|
|American Journal of Gastroenterology|
The team extracted data on endoscopies, esophagitis diagnoses, and gastroesophageal cancer diagnoses from 5 population-based databases.
The team found that the incidence of esophagitis lesions was 2.4 per 1000 person-years in 2002.
They also found that 18.3 per 1000 persons had previously diagnosed esophagitis.
The investigators determined that incidence increased by calendar year and age, it was higher in males than females, and was closely related to rate of endoscopy.
Of the 11,129 patients with previously diagnosed esophagitis, 15 had esophageal adenocarcinoma during 58,322 person-years of follow-up. This equated to 26 per 100,000 person-years.
The team found that 10 of the 15 patients with esophageal adenocarcinoma had previously diagnosed Barrett's esophagus.
Dr Annmarie Lassen's team concluded "The risk of esophageal adenocarcinoma is increased 5-fold in patients with previously diagnosed esophagitis, but most of the adenocarcinomas occurred among patients with Barrett's esophagus".