Despite reports of decreasing hospitalizations and mortality due to peptic ulcer, it is unclear whether the incidence has truly declined over time.
In this study, investigators from the Netherlands analyzed time trends in the incidence of and in hospital admission rates for peptic ulcer.
The team used the nationwide registry of pathology reports (PALGA) and the national registry of hospital admissions (Landelijke Medische Registratie).
They used standardized morbidity ratios to assess the magnitude of the changes.
The researchers found that the age-adjusted incidence of gastric ulcer has halved for both sexes.
Although the number of gastric biopsies obtained at endoscopy has increased, the proportion with a diagnosis of peptic ulcer has decreased by more than 50%.
|The incidence of peptic ulcer halved in men and women.|
|Alimentary Pharmacology and Therapeutics|
The team determined that the admission rate for peptic ulcer has more than halved between 1980 and 2003.
However, they also found that admission rates for complicated ulcers have barely changed and have slightly increased among women.
Dr Post's team concluded, "The incidence of histopathologically confirmed gastric ulcer halved between 1992 and 2003 in the Netherlands".
"As the number of gastric biopsies increased in this period, a true decrease is likely".
"Hospital admissions for peptic ulcer declined dramatically between 1980 and 2003, but remained unchanged or slightly increased for complicated ulcers".