The associations between psychological and endoscopic profiles are not clearly validated among the heterogeneous patients with gastroesophageal reflux disease.
Dr Yi-Chia Lee and colleagues from Taiwan therefore identified any associations by means of cross-sectional study.
The investigative team enrolled consecutive participants in a health screening program.
Definition and severity of erosive esophagitis were assessed with the Los Angeles classification.
The team measured frequency and severity of psychological symptoms with a 30-item Brief Symptom Rating Scale.
Personality traits were measured with a short form of the Maudsley Personality Inventory.
| Brief Symptom Rating Scale parameters were higher in symptomatic subjects|
|Journal of Gastroenterology & Hepatology|
The investigators performed statistical analyses based on the presence of gastroesophageal reflux disease (GERD) symptoms or endoscopic esophagitis.
The team recruited a total of 4600 participants.
Of these subjects, 29% had manifestations suggesting gastroesophageal reflux disease, including non-erosive reflux disease in 11%.
The team noted that 4% had symptomatic erosive esophagitis, and 15% had asymptomatic erosive esophagitis.
The Brief Symptom Rating Scale parameters were significantly higher in symptomatic subjects.
The investigators found that neuroticism scores were also higher in symptomatic subjects.
However, the extroversion scores were lower than those of asymptomatic subjects.
Following logistic regression analysis, independent risk factors for GERD symptoms were female gender, and higher neuroticism scores.
The team observed that for erosive esophagitis, independent risk factors were male gender, and higher body mass index scores.
Dr Lee's team concludes, “Psychological characteristics predict likelihood of gastroesophageal reflux disease symptoms but not structural state of esophagus.”
“Male gender and obesity are risk factors for erosive esophagitis.”
“However, female gender and neuroticism are more likely to be associated with gastroesophageal reflux disease symptoms."