It remains unclear whether Helicobacter pylori eradication accelerates acute gastric ulcer healing after endoscopic mucosal resection of gastric tumors.
Dr Hiroyuki Ueda and colleagues examined the effect of H pylori eradication on ulcer healing after endoscopic mucosal resection.
The team prospectively followed 26 patients who underwent successful H pylori eradication before endoscopic mucosal resection.
Patients underwent endoscopic examination 1 or 2 months after endoscopic mucosal resection.
The research team assessed the ulcer status and reduction rate during this time.
The effect of H pylori eradication on the quality of ulcer healing was also evaluated.
|97% of ulcers were reduced at 2 months after endoscopic mucosal resection|
|Journal of Clinical Gastroenterology|
Controls included 6 patients in whom eradication therapy failed, and 26 patients who underwent endoscopic mucosal resection without eradication.
The researchers found that 75% of ulcers in the eradication group were at the healing stage 1 month after endoscopic mucosal resection.
The team noted that ulcer reduction rates were 85% and 97% at 1 and 2 months after endoscopic mucosal resection, respectively.
Ulcer stage and reduction rate did not differ significantly between the eradication group and control group.
However, the team frequently observed a better quality of ulcer healing in the eradication group than in the control groups.
Dr Ueda's team concluded, “H pylori eradication therapy does not accelerate ulcer healing after endoscopic mucosal resection.”
“However, it may improve the quality of ulcer healing.”