Patients with chronic pancreatitis typically suffer intractable abdominal pain that is resistant to most analgesic strategies.
Recent research indicates that the pain of chronic pancreatitis may be in part due to oxygen free radical induced pancreatic damage.
Dr Gareth Kirk and colleagues from Canada evaluated the efficacy of a combined antioxidant preparation in managing chronic pancreatitis.
The team conducted a randomized, double-blind, placebo-controlled crossover trial.
The research team randomized 36 patients with confirmed chronic pancreatitis to receive treatment with either Antox or placebo for 10 weeks.
| Physical and social functioning, and general health perception was improved after antox|
|Journal of Gastrointestinal Surgery|
Antox contains the antioxidants selenium, betacarotene, L-methionine, and vitamins C and E.
Each group of patients then switched to receive the alternative treatment for a further 10 weeks.
The researchers measured markers of antioxidant status by blood sampling.
Quality of life and pain were assessed using the Short Form-36 questionnaire.
The research team reported that 19 patients completed the full 20 weeks of treatment.
The team found that antox treatment was associated with improvements in quality of life in terms of pain, physical and social functioning, and general health perception.
Dr Kirk's team concluded, “Treatment with antioxidants may improve quality of life and reduce pain in patients suffering from chronic pancreatitis.”