Dr Holm and colleagues from Finland studied the long-term safety of oats in the treatment of children with celiac disease.
The research team enrolled 32 children with celiac disease in a 2-year controlled trial.
The team randomized 23 children in remission either to oats or a gluten challenge.
When small bowel histological relapse was evident after gluten challenge, a gluten-free diet including oats was started.
Furthermore, 9 newly detected celiac patients adopted an oat-containing gluten-free diet.
The team assessed small bowel mucosal morphology, CD3+, αβ+ and γδ+ intraepithelial lymphocytes.
Human leucocyte antigen DR expression and celiac serology were also determined.
|There was complete recovery in newly detected patients on an oat-containing gluten-free diet|
|Alimentary Pharmacology & Therapeutics|
After the trial, the children were allowed to eat oats freely, and follow-up was extended up to 7 years.
The researchers found that in celiac children in remission, oats had no detrimental effect on intestinal histology or serology during the 2-year trial.
In contrast, the team noted that the gluten-challenge group relapsed after 3 to12 months.
Complete recovery from the disease was accomplished in all relapsed and newly detected patients on an oat-containing gluten-free diet.
The team observed that after the trial, 86% of the children preferred to consume oats, and they all remained in remission.
Dr Holm's team concluded, “In most children with celiac disease, long-term consumption of oats is well tolerated, and it does not result in small bowel mucosal deterioration or immune activation.”