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 21 November 2017

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News

Oats are well tolerated in childhood celiac disease

Research in the latest Alimentary Pharmacology & Therapeutics shows that in children with celiac disease, long-term consumption of oats is well tolerated, and does not cause small bowel mucosal deterioration or immune activation.

News image

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Dr Holm and colleagues from Finland studied the long-term safety of oats in the treatment of children with celiac disease.

The research team enrolled 32 children with celiac disease in a 2-year controlled trial.

The team randomized 23 children in remission either to oats or a gluten challenge.

When small bowel histological relapse was evident after gluten challenge, a gluten-free diet including oats was started.

Furthermore, 9 newly detected celiac patients adopted an oat-containing gluten-free diet.

The team assessed small bowel mucosal morphology, CD3+, αβ+ and γδ+ intraepithelial lymphocytes.

Human leucocyte antigen DR expression and celiac serology were also determined.

There was complete recovery in newly detected patients on an oat-containing gluten-free diet
Alimentary Pharmacology & Therapeutics

After the trial, the children were allowed to eat oats freely, and follow-up was extended up to 7 years.

The researchers found that in celiac children in remission, oats had no detrimental effect on intestinal histology or serology during the 2-year trial.

In contrast, the team noted that the gluten-challenge group relapsed after 3 to12 months.

Complete recovery from the disease was accomplished in all relapsed and newly detected patients on an oat-containing gluten-free diet.

The team observed that after the trial, 86% of the children preferred to consume oats, and they all remained in remission.

Dr Holm's team concluded, “In most children with celiac disease, long-term consumption of oats is well tolerated, and it does not result in small bowel mucosal deterioration or immune activation.”

Aliment Pharmacol Ther 2006: 23(10): 1463
05 May 2006

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