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 22 November 2017

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News

Rabbit anti-thymocyte globulin may work better without steroids, in liver transplant rejection

Rabbit ATG may work better without steroids and can improve the outcome of liver transplantation, according to research reported to the American Society of Transplant Surgeons.

News image

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71 transplant recipients were involved in research reported to Transplant 2001, the meeting of the American Society of Transplant Surgeons held in Chicago, USA.

Rabbit ATG is currently indicated for use with steroids in the treatment of acute organ rejection.

But the use of steroids is associated with increased levels of infections, diabetes, and the recurrence of hepatitis C infection.

Rejection rates:
ATG plus steroids: 30%
ATG minus steroids: 20%
Hepatology

The research showed the incidence of rejection decreased when steroids were not used, as did the risk of other complications.

Of the patients on the steroid-free treatment, 50% developed HCV infection and 4% developed diabetes. This contrasted with 70% and 14% incidence rates, respectively, among patients given steroids.

Rejection rates fell from 30% to 20% on the steroid-free treatment.

Researcher Dr James Eason, of the Ochsner Multi-Organ Transplant Center, New Orleans, USA, said, "This study shows that a steroid-free regimen, using low-dose thymoglobulin induction, may decrease the risk for diabetes, infection, and hepatitis C among patients who have undergone liver transplants, in addition to decreasing the incidence of rejection."

Report Copyright: Englemed Health News at http://www.internationalmedicalnews.com

Transplant 2001
15 May 2001

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