Researchers found that healthy spleen cells eradicated the pathogen in mice with deficient immune systems.
|Splenocytes eradicated H. pylori in immune-deficient mice.
|Infection and Immunity|
However, in the study, reported in the journal Infection and Immunity, the spleen cells did not eliminate the infection from mice with normal immune systems.
During the course of the 51-week experiment at Ohio State University, the immune-deficient mice experienced a total disappearance of gastritis caused by H. pylori infection following treatment with splenocytes. All traces of infection also disappeared.
However, the illness continued to develop in animals that had healthy immune systems, even when they were treated with splenocytes.
Researcher Kathryn Eaton said, "The persistence of H. pylori in the healthy mice was consistent with extensive evidence in humans and other animals that the body's immune response - gastritis - fails to eliminate the bacteria.
"If we can determine what subsets of the immune system are important for getting rid of the bacteria in mice, then we could look at two types of people: those who are infected but who don't get sick, and infected individuals who do develop illness."
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