Everyone knows that cannabis stimulates the appetite, although no scientific proof had been found up until now.
Mice that have been genetically-engineered to lack cannabinoid function eat less than normal, show George Kunos of Virginia Commonwealth University in Richmond and his colleagues.
|Cannabinoid levels are under the control of leptin.|
Levels of cannabinoids, like other molecules that direct food intake, are under the control of the key fat-regulator leptin, a hormone that keeps tabs on the energy status of the body.
"This is the first time that the cannabinoid and leptin pathways have been shown to interact," says Raphael Mechoulam of Hebrew University in Israel, who writes an accompanying News and Views article.