Researcher B. Neri and colleagues investigated the use of adjuvant chemotherapy for gastric cancer after curative resection. This is a therapy option that is still subject to discussion.
137 patients with gastric adenocarcinoma, all with positive nodes, were enrolled in the study. All were randomized after curative resection to receive either chemotherapy or no treatment.
69 patients received epidoxorubicin (EPI), leucovorin (LV), and 5-fluorouracil (5-FU) on Days 1-3, every 3 weeks for 7 months. The remaining 68 individuals did not undergo the chemotherapy regime.
|Median survival time after treatment:|
Controls: 18 months
Chemotherapy: 31 months
|British Journal of Cancer|
The researchers found that after a follow-up period of 5 years, 21 of the 69 treated patients (30%) were still alive. Of the controls, 9 (13%) remained alive.
The median survival time was 18 months for the controls, and 31 months for the patients treated with adjuvant chemotherapy.