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 22 May 2018

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News

Excellent post-transplant biliary stricture outcomes after endoscopy

Long-term outcomes with post-liver transplant biliary strictures after endoscopic treatment is excellent, and non-anastomotic strictures reduces graft survival, reports this month's Liver Transplantation.

News image

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Biliary strictures are one of the most common complications following liver transplantation, with an incidence of 6% to 34%.

Endoscopic techniques have been successfully used to treat biliary complications.

However, the long-term efficacy and safety of this treatment option has not yet been fully elucidated.

Dr Ivo Graziadei and colleagues performed a prospective study on the efficacy and safety of endoscopic management of biliary complications after liver transplants.

The research team assessed its impact on long-term patient and graft survival.

Biliary strictures were suspected in the presence of elevated liver parameters and/or abnormal abdominal sonography.

77% of patients with anastomotic strictures had long-term success
Liver Transplantation

The team diagnosed the strictures by endoscopic retrograde cholangiography.

The mean follow-up was 40 months after first endoscopic retrograde cholangiography.

Between 1992 and 2003, a total of 515 patients underwent liver transplantation.

The research team diagnosed biliary complications in16% of patients.

The team found anastomotic strictures alone in 13% and nonanastomotic strictures in 14% of patients.

The researchers observed long-term success in 77% of patients with anastomotic strictures.

In patients with nonanastomotic strictures, partial long-term responses could be achieved in 63% of patients.

The team noted that 6% of patients required a percutaneous, and 7% a surgical approach.

Dr Graziadei's team concluded, “The long-term outcome for patients with post-liver transplant biliary strictures after endoscopic treatment is excellent, especially for patients with anastomotic strictures.”

“Development of non-anastomotic strictures reduces graft but not patient survival after endoscopic therapy.”

Liv Transplant 2006: 12(5): 718-25
01 May 2006

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