Researchers from München, Germany evaluated pre- and postoperative quality of life after laparoscopic Nissen fundoplication for gastroesophageal reflux disease (GERD).
75 patients with GERD were enrolled in the study. Clinical investigations, including esophageal manometry, pH monitoring, and endoscopy, and a previously validated Quality of Life Index, were performed before and a median of 41 months after antireflux surgery.
After laparoscopic Nissen fundoplication, the percentage of total time with a pH less than 4 decreased from 10.4% to 3.2% on 24-hour pH monitoring.
The team found the mean pressure of the lower esophageal sphincter improved from 8.1 to 12.3-mmHg.
|Quality of Life Index scores:|
Prior to surgery: 86
After surgery: 116
Esophagitis healed in 63 of 66 patients in whom it was present prior to surgery.
Additionally, the overall Quality of Life Index improved significantly from 86 to 116.
Researcher C. Möbius concluded on behalf of the group, "Laparoscopic fundoplication provides effective and durable relief of reflux in patients with GERD. The Quality of Life Index showed significant improvement after surgery."