Endoscopic ultrasound-guided fine-needle aspiration is effective for establishing tissue diagnosis in suspected pancreatic cancer.
However, data on the frequency of major complications following this procedure are limited.
Dr Mohamad Eloubeidi and colleagues evaluated the frequency of major complications after endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses.
The research team conducted a prospective cohort study at a tertiary University-based referral center for pancreatico-biliary disorder.
The team included 355 consecutive patients who underwent endoscopic ultrasound-guided fine-needle aspiration of a solid pancreatic mass over a 42-month period.
All immediate complications were recorded by the endosonographer.
Late complications were assessed at 72 hours and at 30-days after the procedure.
The researchers defined major complications as acute pancreatitis, bleeding, infection, perforation, use of reversal medication, hospitalization or death.
The team encountered major complications in 3% of patients.
Acute pancreatitis occurred in 3 patients, of which 2 were hospitalized, and 1 recovered with outpatient analgesics.
|2% of patients were hospitalized for complications after the procedure|
The researchers noted that 3 patients were admitted for severe pain after the procedure.
All were treated with analgesics and subsequently discharged with no sequela.
The team observed that 2 patients developed fever, and were admitted for intravenous antibiotics.
Of these, 1 patient recovered with intravenous antibiotics and the other required surgical debridement for necrosis.
The researchers noted that 1 patient required the use of reversal medication.
Overall, the team found that 2% of the patients were hospitalized for complications.
None of the patients experienced clinically significant hemorrhage, perforation, or death.
The research team identified no clear predisposing risk factors.
However, the team noted a lack of surgical gold standard and referral to a tertiary center.
Dr Eloubeidi's team concluded, “Endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses infrequently leads to major complications.”
“The results can be used by endosonographers to counsel patients before endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses."