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 20 April 2018

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News

Barrett's and not PPI use is associated with colorectal neoplasia

Barrett's esophagus, increasing age and alcohol use are factors associated with colorectal neoplasia risk, independent from the use of PPIs or aspirin and nonsteroidal anti-inflammatory drugs, finds April's Gastrointestinal Endoscopy.

News image

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It has been suggested that Barrett's esophagus is associated with an increased risk of developing colorectal neoplasia, but this has not been reported consistently.

Dr Peter Siersema and colleagues studied whether Barrett's esophagus is associated with an increased risk of colorectal neoplasia.

The investigative team assessed whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs.

The team conducted a retrospective case-control study using the endoscopic database of the Palo Alto Veterans Affairs Health Care System.

The investigators matched 268 veterans with Barrett's esophagus with 268 controls without Barrett's esophagus.

Controls had undergone upper gastrointestinal endoscopy within 14 days of the corresponding case.

Colorectal neoplasia occurred in 60% with Barrett's esophagus vs 40% in controls
Gastrointestinal Endoscopy

Colonoscopy was performed within 6 months in cases and controls.

The investigators found that colorectal neoplasia was present in 60% of Barrett's esophagus patients and in 40% of controls.

The presence of Barrett's esophagus, but also increasing age and alcohol use were associated with an increased risk of colorectal neoplasia.

In addition, the team noted that use of proton-pump inhibitors, and aspirin or nonsteroidal anti-inflammatory drugs had no meaningful effect.

Dr Siersema's team commented, “Veterans with Barrett's esophagus are at an increased risk of developing colorectal neoplasia.”

“This association is independent from the use of proton-pump inhibitors or aspirin/ nonsteroidal anti-inflammatory drugs.”

Gastrointest Endoscopy 2006: 63(4): 581-6
11 April 2006

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