No previous correlation between phenotype at diagnosis of Crohn's disease, and mortality has been performed.
Dr Wolters and colleagues assessed the predictive value of phenotype at diagnosis on mortality in a European cohort of Crohn's disease patients.
Overall and disease related mortality were recorded 10 years after diagnosis.
The research team collected data from a prospectively assembled, uniformly diagnosed European population based inception cohort.
There were 380 Crohn's disease patients diagnosed between 1991 and 1993.
The team calculated standardized mortality ratios for geographic and phenotypic subgroups at diagnosis.
The researchers observed 37 deaths in the entire cohort whereas 22 deaths were expected.
|Excess mortality was mainly due to gastrointestinal causes related to Crohn's|
Mortality risk was significantly increased in both females and males.
The team noted that patients from northern European centers had a significant overall increased mortality risk.
A tendency towards increased overall mortality risk was also observed in the south.
The team found that mortality risk was increased in patients with colonic disease location and with inflammatory disease behavior at diagnosis.
Mortality risk was also increased in the age group above 40 years at diagnosis for both total and Crohn's disease related causes.
The researchers identified that excess mortality was mainly due to gastrointestinal causes that were related to Crohn's disease.
Dr Wolters' team commented, “This European multinational population based study revealed an increased overall mortality risk in Crohn's disease patients 10 years after diagnosis.”
“Age above 40 years at diagnosis was found to be the sole factor associated with increased mortality risk.”