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 18 February 2018

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News

Lower survival with liver grafts from cardiac death donors

Liver allografts from cardiac death donors may increase the cadaveric donor pool, however, favorable graft survival rates are achieved when low-risk grafts are transplanted in a low-risk setting, finds April's American Journal of Transplantation.

News image

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There is an increased use of allografts from donation after cardiac death donors.

Dr Mateoa and colleagues from California therefore evaluated liver transplants and donation after cardiac death.

The research team assessed the impact of recipient and donor factors on graft survival.

Liver transplants from cardiac death donors reported to UNOS were analyzed against donation after brain death donor liver transplants between 1996 and 2003.

The researchers defined a recipient cumulative relative risk using significant risk factors identified from a Cox regression analysis.

The significant risk factors included age, medical condition at transplantation, regraft status, dialysis received and serum creatinine.

The team found that graft survival from donation after cardiac death donors was 71% at 1 year, and 60% at 3 years.

Graft survival from cardiac death donors was 71% at 1 year vs 80% from brain death donors
American Journal of Transplantation

These were significantly inferior to donation after brain death donors, with 80% survival at 1 year and 72% at 3 years.

Low-risk recipients with low-risk donation after cardiac death livers achieved graft survival rates of 81% and 67% at 1 and 3 years, respectively.

The team observed that the results for low-risk recipients did not differ significantly from recipients with donation after brain death allografts.

Dr Mateoa's team commented, “Liver allografts from donation after cardiac death donors may be used to increase the cadaveric donor pool.”

“Favorable graft survival rates achieved when low-risk grafts are transplanted in a low-risk setting.”

“Whether transplantation of these organs in low-risk recipients provides a survival benefit compared to the waiting list is unknown.”

Am J Transplant 2006: 6(4): 791
04 April 2006

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