Inflammatory bowel disease (IBD) is associated with an increased risk for colorectal cancer.
However, the genetic, endoscopic, and histologic features of IBD-associated colorectal cancer differ from cancers that arise sporadically.
Dr Delaunoit and colleagues described the clinicopathologic features of IBD-associated colorectal cancer.
The research team compared survival rates between patients with IBD-associated colorectal cancer, and patients with sporadic colorectal cancer.
|55% of IBD-related tumors were distal to the splenic flexure vs 78% of sporadic tumors|
|Clinical Gastroenterology & Hepatology|
The team assessed 290 patients with IBD-associated colorectal cancer, of which 241 had chronic ulcerative colitis and 49 had Crohn's disease.
There were an equal number of age- and sex-matched sporadic colorectal cancer patients who were evaluated at the Mayo Clinic between 1976 and 1996.
The researchers reviewed medical records retrospectively.
Demographic features, endoscopic and histologic characteristics, and vital status at the time of the last follow-up evaluation was evaluated.
The actuarial survival of each group was calculated by the Kaplan-Meier method.
The team used the Cox proportional hazards regression modelling to assess the influence of clinical features on survival.
The median age at diagnosis of IBD-related colorectal cancer was 48 years.
The team found that 55% of IBD-related tumors were distal to the splenic flexure compared with 78% of sporadic tumors.
During a median follow-up period of 5 years, 56% IBD-associated colorectal cancer patients died vs 57% with sporadic colorectal cancer.
The researchers observed that the 5-year survival rates were 54% in the IBD- colorectal cancer subgroup vs 53% in the sporadic colorectal cancer subgroup.
Dr Delaunoit's team concluded, “Chronic ulcerative colitis-related colorectal cancer is diagnosed at a relatively young age.”
“IBD-related tumors tend to be distributed more evenly across the colorectum than sporadic tumors.”
“The survival rates for IBD-associated and sporadic colorectal cancer were similar.”