Patients with esophageal cancer often display relapse at cervical nodes after surgery, but their prognosis and a suitable therapy remains unknown.
Dr Yano and colleagues retrospectively reviewed the records for 35 patients who underwent esophagectomy with lymphadenectomy.
The patients displayed relapse at the cervical lymph nodes alone between 1985 and 2003.
The researchers observed the prognostic factors for such patients.
Median survival time from the date of recurrence for all 35 patients was 12 months.
The team observed that 1-year, 2-year, 3-year and 5-year survival rates was 47%, 27%, 18% and 9%, respectively.
With regard to the initial treatment against cervical node recurrence, 15 patients were treated by radiotherapy alone.
|Number of relapsed nodes was a significant prognostic factor|
|Diseases of the Esophagus|
A further 8 were treated by chemoradiotherapy, 11 by surgery and 1 by chemotherapy alone.
Univariate analysis revealed that cervical node dissection at the prior esophagectomy was a prognostic factor.
The researchers noted that time to recurrence, and the number of relapsed nodes were also significant prognostic factors.
Among these factors, the team observed that the number of relapsed nodes was found to be the only significant prognostic factor with an odds ratio of 2.4.
Dr Yano's team concluded, “Cervical node metastasis is generally considered to be distant organ metastasis.”
“However, if it is a solitary node recurrence, substantial survival can be attained by appropriate loco-regional therapy.”