Dr Pandolfino and colleagues analyzed the relationship between obesity and esophagogastric junction pressure segment using high-resolution manometry.
The research team included 285 patients, of which 108 were men, aged between 18 and 87 years.
A solid-state manometric assembly with 36 circumferential sensors spaced 1 cm apart was placed transnasally.
The team measured simultaneous intra-esophageal and intragastric pressures over 6 to 8 respiratory cycles.
|Body mass index and waist circumference correlated with intragastric pressure|
Lower esophageal sphincter and crural diaphragm separation was quantified by measuring the distance between the 2 pressure elements during inspiration.
The association between anthropometric variables and pressure values were examined using univariate and multivariate analysis.
The researchers found a significant correlation of body mass index and waist circumference with intragastric pressure.
The team observed that gastroesophageal pressure gradient was also correlated to body mass index and waist circumference.
Multivariate analysis adjusting for age, gender, and patient type did not alter the direction or magnitude of this relationship.
In addition, the team noted that obesity was associated with separation of the esophagogastric junction pressure components.
Dr Pandolfino's team concluded, “Obese subjects are more likely to have esophagogastric junction pressure disruption leading to hiatal hernia.
"These subjects are also more likely to have an augmented gastroesophageal pressure gradient providing a perfect scenario for reflux to occur.”
“Whether or not weight loss can reverse these abnormalities is unknown.”