The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNβ3.
Dr Christopher Camilleri explored the association of candidate genotypes in dyspepsia in a sample from a US community.
The research team assessed whether altering adrenergic, serotonergic, CCKergic, and G protein functions was associated with dyspepsia.
Dyspeptics and healthy controls were identified among community respondents who had been randomly selected to complete validated questionnaires.
The researchers excluded other diseases by face-to-face history and physical examination.
Polymorphisms of candidate genes for α2A, α2C, 5-HT1A, 5-HT2A, 5-HT2C, CCK-1 receptors and CCK promoter, GNβ3 protein, and SERT-promoter were studied.
The team studied the association between polymorphisms and meal-related or meal-unrelated dyspepsia.
| Using Rome II subgroups, the same genotype was associated with dysmotility-like dyspepsia|
|American Journal of Gastroenterology|
High somatic symptom scores, and somatization were evaluated using Fisher's exact test.
DNA was available from 41 dyspeptics and 47 healthy controls from Olmsted County.
The team found that community dyspepsia unrelated to meals was associated with both homozygous GNβ3 protein 825T and C alleles.
There were no significant associations with meal-related dyspepsia.
Using Rome II subgroups, the team noted that the same genotype was associated with dysmotility-like and other dyspepsia.
Higher somatization scores were not significantly associated with any of the candidate genes when considered as single factors.
Dr Camilleri's team concluded, “Meal-unrelated dyspepsia in a US community study is associated with the homozygous 825T or C alleles of GNβ3 protein.”
“Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.”