The stomach is the most frequent site of intestinal lymphomas.
However, few data are available on both clinical endoscopic presentation of gastric lymphoma and differences between low-grade and high-grade lymphomas.
Dr Zullo and colleagues from Italy retrieved clinical, histological and endoscopic records of patients with primary low-grade or high-grade lymphoma.
Symptoms were categorized as 'alarm' or 'not alarm'.
The research team classified the endoscopic findings as 'normal' or 'abnormal'.
Overall, 144 patients with primary gastric lymphoma were detected, including 74 low-grade and 70 high-grade lymphoma.
Alarm symptoms particularly included persistent vomiting and weight loss.
The team noted that these were present in 54% of patients with high-grade lymphoma vs 28% in those with low-grade lymphoma.
| 54% with high-grade lymphoma had alarm symptoms vs 28% with low-grade lymphoma|
|Alimentary Pharmacology & Therapeutics|
Low-grade lymphomas presented as 'normal' appearing mucosa or petechial haemorrhage in the fundus more frequently than high-grade lymphomas.
The researchers found that low-grad lymphomas were also more often confined to the antrum, and associated with Helicobacter pylori infection.
On the contrary, the team noted that high-grade lymphomas presented more commonly as ulcerative type.
High-grade lymphomas were also more frequently diagnosed in stage I or above when compared with low-grade lymphomas.
Dr Zullo's team concludes, “The overall prevalence of alarm symptoms is quite low and may be absent in more than 70% of patients with low-grade lymphoma.”