Gastroenterologists at the Rush Presbyterian St Luke's Medical Center, Chicago, USA, tested the treatment on 20 patients with chronic proctitis caused by radiation.
Patients took a tablet of each vitamin 3 times a day for 8 weeks.
The effectiveness of the treatment was measured using questionnaires.
Assessments showed significant improvements in bleeding, diarrhea, and urgency, according to the researchers. The treatment made no difference to rectal pain.
13 patients reported improvements in lifestyle, including 7 who said they returned to normal.
Researcher Dr Keith Bruninga said: "Our study showed that we can harness the potent antioxidant properties of the vitamins to repair cell damage and bring relief to many people who suffer from the persistent,lifestyle-altering symptoms of chronic radiation proctitis.
"If our continued research shows that the antioxidant regimen is successful in treatment of this illness, we plan to investigate its use to prevent chronic radiation proctitis."
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