Evidence for an association between dietary fiber and colorectal neoplasia has been equivocal.
Some data suggest that there may be sex differences in response to fiber.
Dr Elizabeth Jacobs and colleagues determined whether fiber affects colorectal adenoma recurrence differently in men and women.
The investigative team combined the study populations of 2 large clinical intervention trials.
Data from the Wheat Bran Fiber Trial and the Polyp Prevention Trial were pooled.
The investigators analyzed the data from 3209 participants using logistic regression models.
The adjusted odds ratio for adenoma recurrence for those in the intervention group of either trial was 0.9.
|Men had a significantly reduced odds of recurrence with an odds ratio of 0.8|
|American Journal of Clinical Nutrition|
For men, the intervention was associated with statistically significantly reduced odds of recurrence with an odds ratio of 0.8.
The investigators observed no significant association for women.
Using a likelihood-ratio test, the team found a statistically significant interaction between intervention group and sex.
Dr Jacobs' team concludes, “The results of the current analyses indicate that men may experience more benefit from dietary fiber than do women.”
“This may help to explain some of the discrepant results reported in the literature.”