A team from the Western Infirmary, Glasgow, Scotland, assessed the duration of rebound maximal acid hypersecretion after omeprazole treatment.
Nine Helicobacter pylori-negative healthy subjects who received an 8-week course of omeprazole 40mg/day were included in the study.
|Maximal acid output was elevated by 19.6% at 11 months after omeprazole therapy.
British Society of Gastroenterology Annual Meeting|
Each individual was assessed with pentagastrin-stimulated maximal acid output studies at 1,2,4,6, and 8 weeks and 11 months after the treatment.
Their findings were presented at the British Society of Gastroenterology Annual Conference, being held this week in Glasgow.
The researchers found that the mean percentage increase in maximal acid output (MAO) after omeprazole treatment was 41.1% at Week 1. The percentage increases were 58.7, 43.2, 30.0, and 32.0 for Weeks 2, 4, 6, and 8, respectively. The MAO was found to remain significantly elevated, at 19.6% at 11 months.
Researcher D. Gillen concluded on behalf of the group, "This prolonged acid hypersecretion by the stomach might have implications for withdrawal of treatment with omeprazole."