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 21 November 2017

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Weight gain associated with gastroesophageal reflux symptoms

This month's issue of the American Journal of Gastroenterology shows that weight gain is associated with gastroesophageal reflux symptoms, independently of body mass index.

News image

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Excess weight is a risk factor of gastroesophageal reflux symptoms in population-based studies.

However, it is unknown to what extent short-term weight gain is associated with the development of gastroesophageal reflux symptoms.

Dr Enrique Rey and colleagues from Minnesota examined the association of weight gain with gastroesophageal reflux symptoms.

A phone interview was conducted with 2500 persons aged 40 to 79 years selected at random from the general population of Spain.

The team used the Gastroesophageal Reflux Questionnaire to identify the onset, frequency, and severity of gastroesophageal reflux symptoms.

The research team also assessed weight, height, and 1-year weight change.

More than 5 kg weight gain had an adjusted odds ratio of 3 with new symptoms
American Journal of Gastroenterology

The team then compared the frequency of new, or less than 1 yr duration, and old, defined as 1 year or more duration of symptoms in weight change subgroups.

The association between weight change and gastroesophageal reflux symptoms was analyzed by logistic regression.

The model adjusted for body mass index and other potential confounders.

The researchers found that the prevalence of new and old gastroesophageal reflux symptoms, respectively, was higher in subjects with more than 5kg weight gain.

Subjects with a 5kg weight gain or less showed an adjusted odds ratio of 1.5 for new gastroesophageal reflux symptoms.

The team noted that for old gastroesophageal reflux symptoms, subjects with the 5kg or less weight gain had an adjusted odds ratio of about 1.

Those with a weight gain more than 5 kg showed an adjusted odds ratio of 3 for new gastroesophageal reflux symptoms and of 1.3 for old symptoms.

Dr Rey's team comments, “Weight gain is associated with gastroesophageal reflux symptoms, independently of body mass index.”

Am J Gastroenterol 2006: 101(2): 229
09 February 2006

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