Dr Tai Nin Chau and colleagues from China compared the epidemiology and clinical features of 2 enterically transmitted hepatitis, namely Hepatitis E and Hepatitis A.
The investigators analyzed clinical features and risk factors of 105 cases of Hepatitis A and 24 cases of Hepatitis E admitted in 2002.
All patients were tested positive for IgM antibody against either Hepatitis A virus or Hepatitis E virus.
Patients were tested to be negative for IgM anti-Hepatitis B virus or IgG anti-Hepatitis C virus.
Hepatitis A patients were significantly younger, with a median age of 27 years, and most had a recent history of shellfish consumption.
| Hepatitis E patients were older, and most had a recent travel history|
|American Journal of Gastroenterology|
The investigators found that Hepatitis E patients were older, with a median age of 53 years, and most had a recent travel history.
The investigative team noted that Hepatitis A was milder and recovery was uneventful.
However, the team noted that Hepatitis E was more severe.
Hepatitis E was associated with significant mortality, and frequently complicated by protracted coagulopathy and cholestasis.
Dr Chau's team commented, “Hepatitis E is a more severe disease entity as compared with Hepatitis A, and a significant proportion of them are imported cases from an endemic area.”