Dr Buzzoni and colleagues investigated the pattern and timing of recurrence of gastric cancer after radical resection.
The research team also determined associated risk factors after radical resection of gastric cancer including D2 dissection.
The team examine a total of 274 patients who had undergone radical resection of gastric cancer.
Patients with nodal involvement or T3 to T4 tumors were randomized to receive chemotherapy or no further treatment.
Locoregional recurrence and distant metastasis were analyzed in a competing risks framework.
The team estimated the crude cumulative incidence in each group.
The researchers used multiple regression models to investigate the influence of treatment and pathological features on the risk of recurrence.
|The 7 year rate of locoregional relapse was 16%|
|British Journal of Surgery|
Overall, the 7 year rate of locoregional relapse was 16% and that of distant recurrence was 35%.
The team observed a significant association between pathological node stage and distant relapse.
The researchers noted an association between pathological tumor stage and locoregional recurrence.
Chemotherapy had no significant effect on either locoregional or distant recurrence.
Dr Buzzoni's team commented, “The rate of locoregional recurrence after radical surgery for gastric cancer was lower than that in studies based on more conservative surgery.”
“The pathological tumor stage was related to the rate of locoregional recurrence whereas pathological node stage had an impact on distant recurrence.”