Chronic alcohol intake and chronic Hepatitis C may progress to cirrhosis and hepatocellular carcinoma.
However, few data are available about survival and probability of developing hepatocellular carcinoma in decompensated cirrhosis of both etiologies.
Dr Ricard Solà and colleagues identified risk factors of hepatocellular carcinoma and survival in alcoholic cirrhosis.
The investigative team included 377 consecutive patients with decompensated Hepatitis C-related cirrhosis or alcoholic cirrhosis.
The team also evaluated the differences between both etiologies.
The patients did not have known hepatocellular carcinoma, and were hospitalized for their first hepatic decompensation.
|Child-Turcotte-Pugh score was independently correlated with survival|
Patients were followed for a mean period of 39 months.
During follow-up, 11% developed hepatocellular carcinoma and 35% of patients died.
The investigators found that age and Hepatitis C-cirrhosis were independently related to hepatocellular carcinoma development.
However, the team noted that baseline age and Child-Turcotte-Pugh score were independently correlated with survival.
Dr Solà's team commented, “Survival in decompensated Hepatitis C-related or alcoholic cirrhosis is influenced by age and baseline Child-Turcotte-Pugh score, without differences in cirrhosis etiology.”
“The risk of developing hepatocellular carcinoma is greater in Hepatitis C-related cirrhosis than in alcoholic cirrhosis.”