The researchers assessed whether a reduction of microparticles in the diet improved the symptoms of Crohn's disease.
They reported their findings in the February issue of the European Journal of Gastroenterology and Hepatology.
20 patients with active corticosteroid-treated ileal or ileo-colonic Crohn's disease were enrolled in the double blind study. Each randomly received either a low microparticle diet (trial group; n = 10) or a control diet (n = 10) for 4 months.
|7 patients were in remission after receiving a low microparticle diet.
|European Journal of Gastroenterology and Hepatology|
Crohn's disease activity index (CDAI) and corticosteroid requirements were compared.
One patient in each group was withdrawn.
The team found that in the trial group there was a progressive decrease in CDAI from entry (392), to month 4 (145), and 7 patients were in remission (CDAI <150).
In contrast, the control group had returned to baseline levels (302 on entry and 295 at month 4), with none in remission.
Corticosteroid intake was reduced more in the trial group, although this did not reach significance.
Researcher Miranda Lomer concluded on behalf of the group, "A low microparticle diet may be effective in the management of ileal Crohn's disease and could explain the efficacy of elemental diets, which similarly are low in microparticles."