Celiac disease is associated with an increased risk of non-Hodgkin lymphoma.
However, there is little information about whether this is true for clinically silent celiac disease.
Dr Luisa Mearin and colleagues investigated the frequency of celiac disease in 2 European populations.
The populations studied included 1 with non-Hodgkin lymphoma and another was derived from the general population.
The team conducted a prospective, multi-center, case-control study in 10 European countries between 1998 and 2001.
| The risk was not present in patients with silent celiac disease detected by screening|
|European Journal of Gastroenterology and Hepatology|
A total of 1446 consecutive patients with newly diagnosed non-Hodgkin lymphoma aged over 18 years was collected.
The control group consisted of a population of 9676 individuals who were screened for celiac disease.
The researchers detected the number of patients with a previous diagnosis of celiac disease and those with silent celiac disease by screening.
The patients with celiac disease had a significantly increased risk of developing non-Hodgkin lymphoma.
The team noted that this risk was only present in patients with celiac disease diagnosed clinically before the study.
The risk was not present in those with silent celiac disease detected by screening.
Dr Mearin's team commented, “Patients with celiac disease have an increased risk of developing non-Hodgkin lymphoma, although this is lower than previously thought.”
“Clinically silent celiac disease is rare in patients with non-Hodgkin lymphoma.”