Benign recurrent intrahepatic cholestasis is characterized by episodic cholestasis and pruritus without anatomical obstruction.
Effective medical treatment is not available.
Dr Roderick Houwen and colleagues assessed serum bile salt after endoscopic nasobiliary drainage.
| Relative amounts of phospholipids and bile salts in bile appeared to be normal|
The team measured serum bile salt concentrations in cholestatic benign recurrent intrahepatic cholestasis patients within 24 hours of nasobiliary drainage.
The team found complete and long-lasting disappearance of pruritus and normalization of serum bile salt.
Relative amounts of phospholipids and bile salts in bile collected during nasobiliary drainage appeared to be normal.
However the investigators observed that phospholipids other than phosphatidylcholine, and especially sphingomyelin, were increased.
Dr Houwen's team conclude, “We propose that temporary endoscopic nasobiliary drainage should be considered in cholestatic benign recurrent intrahepatic cholestasis patients.”