Symptoms of functional gastrointestinal (GI) disorders associated with mood disorders occur in some patients with quiescent inflammatory bowel disease (IBD).
The mood disorders include depression and anxiety, and could be caused by changes in gut motility, visceral hypersensitivity, or psychological dysfunction.
Dr Forough Farrokhyar and colleagues assessed the prevalence of GI symptoms and mood disorders in patients with quiescent IBD.
The research team evaluated the impact on health related quality of life and use of health resources.
The team surveyed 361 patients, of which 149 had IBD during the previous 12 months.
| Mood disorders occurred in 27% with ulcerative colitis and 31% with Crohn's disease |
|Inflammatory Bowel Diseases|
Of the included patients, 44 had ulcerative colitis, and 105 had Crohn's disease.
The patients completed a survey of Rome II criteria for functional gastrointestinal disorders, as well as the Hospital Anxiety and Depression Survey.
Health related quality of life indices, and health resource utilization were assessed.
The team used logistic and linear regression analyses to test for predictors of functional gastrointestinal disorders and health related quality of life.
The research team found symptoms of at least 1 functional gastrointestinal disorder in 82%.
Functional anorectal disorders were the most prevalent followed by functional bowel disorders.
The team noted that both were of greater prevalence than in the general population.
Irritable bowel syndrome symptoms were more common in inactive Crohn's disease than in ulcerative colitis.
The researchers observed that functional constipation was more common in inactive ulcerative colitis than in Crohn's disease.
Mood disorders occurred in 27% of ulcerative colitis and 31% of Crohn's disease patients.
The team identified that age 40 years or older, and anxiety independently predicted functional gastrointestinal disorders.
Both functional gastrointestinal disorders symptoms and mood disorders were associated with impaired health related quality of life.
In addition, the team found that both were associated with an increased use of health services.
Dr Farrokhyar's team commented, “Many patients with inactive inflammatory bowel disease have symptoms compatible with functional gastrointestinal disorders.”
“Both functional gastrointestinal disorders-like symptoms and mood disorders are associated with impaired health related quality of life and increased health resource utilization.”
“Recognition and treatment of functional gastrointestinal disorders and mood disorders could potentially improve daily functioning of inflammatory bowel disease patients.”