Case reports have suggested that statins may cause acute pancreatitis.
Dr Thisted and colleagues examined if statins are associated with risk of acute pancreatitis.
The research team identified 2576 first-time admitted cases of acute pancreatitis from hospital discharge registers in 3 Danish counties.
The team assessed 25,817 age- and gender-matched controls from the general population.
Prescriptions for statins prior to admission with acute pancreatitis or index date among controls were retrieved from prescription databases.
| Odds ratios for acute pancreatitis was 1.0 among new users of statins vs 2.0 in former users|
|Alimentary Pharmacology & Therapeutics|
The researchers used conditional logistic regression analysis to estimate odds ratios for acute pancreatitis among 4 groups of statin users.
Group 1 included those who have ever before used statins, and Group 2 consisted of current or 0 to 90 days before users.
Group 3 included those where a new or first prescription was taken 0 to 90 days before.
Former users were in Group 4 with treatment taken more than 90 days, but not 0 to 90 days before.
Adjusted odds ratios for acute pancreatitis among ever, current, new and former users of statins were 1.4, 1.3, 1.0 and 2.0, respectively.
The researchers found an inverse association between the number of filled prescriptions and risk of acute pancreatitis.
Dr Thisted's team commented, “Our findings speak against a strong causative effect of statins on the risk of acute pancreatitis, and may even indicate a mild protective effect.”