Recent reports have indicated a rising incidence of gastric carcinoids.
Dr Hodgson and colleagues evaluated the incidence pattern of gastric carcinoids in 2 large population-based cancer registries.
The Florida Cancer Data System, Florida's statewide cancer registry, and the Surveillance, Epidemiology, and End Results program were used.
The study population was defined as all cases of gastric carcinoid identified in either database from 1981 to 2000.
|Incidence rates increased from 0.04 per 100,000 to 0.2|
The investigators calculated descriptive statistics and age-adjusted incidence rates.
There were 326 cases of gastric cancer in Florida's statewide registry.
The team noted 594 Surveillance, Epidemiology, and End Results cases of invasive gastric carcinoid during the 20-year study period.
The investigative team reported that the mean age of the patients was 65 years.
The team found that the age-adjusted incidence rate in Florida Cancer Data System increased from 0.04 per 100,000 to 0.2 in the year 2000.
The estimated annual percentage change in incidence was 8 in the Florida Cancer Data System and 9 in Surveillance, Epidemiology, and End Results.
The investigators observed a decrease in gastric cancer was noted during this same period.
Dr Hodgson's team concludes, “This study documented a statistically significant 8- or 9-fold increase in the incidence of gastric carcinoids in 2 large databases.”
“The temporal increase in incidence correlates with the introduction and widespread use of proton pump inhibitors since the late 1980s.”
“Other explanations include improved detection with wider application of upper endoscopy.”
“Further epidemiologic studies are warranted.”