The pathophysiology of functional dyspepsia has not been elucidated precisely.
The effective management of functional dyspepsia has not yet been found.
Until now, treatment with antianxiety or antidepressive agents has been empirically applied.
However, the efficacy of these treatments has not been established.
Dr Mariko Hojo and colleagues from Japan estimated the efficacy of these treatment approaches.
The researchers systematically reviewed the literature concerning trials with agents that are efficacious against anxiety, neurosis, or depression.
| Dyspeptic symptoms were improved in 11 of 13 studies|
|Journal of Gastroenterology|
The research team searched articles from the MEDLINE database in 2003.
The team searched terms such as “antianxiety agents”, “antidepressants”, and “dyspepsia”, reviewed reference lists of published articles.
Finally, studies in which the effectiveness of drugs was clearly stated were selected from the retrieved articles.
The researchers selected 13 articles, on 1717 patients, from among 90 articles retrieved through the literature search.
In 11 of the 13 studies, dyspeptic symptoms were improved significantly by treatment.
Statistical analysis of 4 trials showed a significant benefit of treatment with antianxiety or antidepressive agents.
However, the team found that funnel plots were asymmetric.
Dr Hojo's team concluded, “Antianxiety or antidepressive agents may be effective in the treatment of functional dyspepsia patients, though further clinical trials are necessary.”