Dr Targarona Modena and colleagues from Peru evaluated the capacity of enteral nutrition in avoiding pancreatic necrosis infection in the severe acute pancreatitis.
The investigative team compared enteral nutrition with the total parenteral nutrition plus antibiotic therapy.
Between 1998 and 2003, 87 patients met the inclusion criteria and took part in the research.
Within the first week from their admission, 43 patients received total parenteral nutrition and 44 patients received total enteral nutrition.
The investigators used an adequate prophylactic antibiotic therapy in both groups.
|Death rate was 35% with total parenteral nutrition, vs 5% with total enteral nutrition|
The severity of the manifestations was similar for both groups having a tomographic 'severity index' of 8.
The team reported that the severity of manifestations was similar in both groups for an entry C-reactive protein of 208 and 203 mg/l, respectively.
The investigators found that the group receiving total parenteral nutrition suffered an organ failure in 79% of the cases.
The percentage showed by the group that received total enteral nutrition was 31%, 88% and 25% of the patients in each group requiring a surgical intervention, respectively.
There was a 20% decreased presence of pancreatic necrosis infection in the group of patients that was supplied with total enteral nutrition.
The investigators observed that pancreatic necrosis infection reached 74% in the group receiving total parenteral nutrition.
The team noted a 35% death rate among the patients who received total parenteral nutrition, vs 5% for patients received total enteral nutrition.
Dr Targarona Modena's team commented, “Total enteral nutrition could be used as a prophylactic therapy for infected pancreatic necrosis since it significantly diminished the necrosis infection as well as the mortality.”