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 27 May 2018

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News

Hep C RNA levels predict end-stage liver disease

Hepatitis C RNA level is a predictor of end-stage liver disease death among persons with chronic Hepatitis C infection, reports the latest issue of Hepatology.

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Persons chronically infected with Hepatitis C virus, some of whom are coinfected with HIV and human T-lymphotropic virus type II, are at high risk for end-stage liver disease.

Dr Michie Hisada and colleagues from Maryland evaluated whether end-stage liver disease death was associated with premorbid Hepatitis C RNA level.

The research team also assessed whether end-stage liver disease death whether it was associated with specific Hepatitis C protein antibodies.

The team evaluated a cohort of 6570 injection drug users with or without HIV/ human T-lymphotropic virus type II coinfection.

The patients were enrolled in 9 cities in the USA between 1987 to 1991.

The researchers compared 84 end-stage liver disease descendents and 305 randomly selected cohort participants with detectable Hepatitis C RNA.

Hep C RNA levels remained significant after adjustment for alcohol use
Hepatology

The team stratified the patients by sex, race, HIV, and human T-lymphotropic virus type II strata.

Relative hazard of end-stage liver disease death was derived from the proportional hazard model.

The team found that risk of end-stage liver disease death was unrelated to the intensity of antibodies against the Hepatitis C virus.

The team noted that the risk of end-stage liver disease increased with Hepatitis C RNA level.

The association between Hepatitis C RNA level and end-stage liver disease death remained significant after adjustment for alcohol consumption.

The team observed that the 45 deaths from AIDS and 43 from other causes were unrelated to Hepatitis C RNA.

HIV infection was not associated with end-stage liver disease risk in multivariate analyses adjusted for Hepatitis C RNA.

The researchers found that men had an increased risk of end-stage liver disease death in unadjusted analyses but not in multivariate analysis.

Non-black patients were at increased risk for end-stage liver disease death.

Dr Hisada's team concluded, “Hepatitis C RNA level is a predictor of end-stage liver disease death among persons with chronic Hepatitis C infection.”

Hepatol 2005: 42(6): 1446-52
05 December 2005

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