Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 20 April 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Non-invasive tool for disease activity in ulcerative colitis

Polymorphonuclear neutrophil-elastase, calprotectin, and lactoferrin are markers of disease activity in ulcerative colitis, and, used in a composite index may be a noninvasive tool, reports December's Inflammatory Bowel Diseases

News image

fiogf49gjkf04

Dr Jost Langhorst and colleagues evaluated the diagnostic use of indicators of disease activity in active and inactive ulcerative colitis.

The research team assessed fecal concentrations of lactoferrin, calprotectin, polymorphonuclear neutrophil-elastase, and lysozyme.

The researchers collected a total of 76 fecal specimens from 31 patients with ulcerative colitis in times of active and inactive status of disease.

Disease activity was determined with the colitis activity index.

The colitis activity index includes a combination of laboratory parameters and clinical symptoms, with a score of at least 6 indicating active disease.

The team measured fecal lactoferrin, calprotectin, polymorphonuclear neutrophil-elastase, and lysozyme reported as micrograms per milliliter feces.

A composite index based on these 3 markers had a sensitivity of 88%
Inflammatory Bowel Diseases

Levels of more than 7 for lactoferrin, and more than 6 for calprotectin were considered elevated as specified by the manufacturers.

For polymorphonuclear neutrophil-elastase, levels of more than .06, and at least 0.6 for lysozyme were considered elevated as specified by the manufacturers.

Based on the colitis activity index classification, 25 of the samples were from patients with active disease status and 51 were from patients with inactive status.

The team noted that lactoferrin, and calprotectin showed increased levels in samples from patients in active disease compared with those in remission.

The researchers also found that polymorphonuclear neutrophil-elastase but not lysozyme showed increased levels in samples from patients in active disease.

The research team observed that all 4 parameters correlated with the colitis activity index.

Introducing a composite index based on lactoferrin, calprotectin, and polymorphonuclear neutrophil-elastase, the specificity was 73%.

In addition, the team found that the composite index based on these 3 markers had a sensitivity of 88% compared with the colitis activity index.

Dr Langhorst's team concludes, “Among the neutrophil-derived proteins in feces, polymorphonuclear neutrophil-elastase, calprotectin, and lactoferrin represent useful markers of disease activity in patients with ulcerative colitis.”

“Using all 3 markers in a composite index may be an additional noninvasive tool for the management of ambulant patients with ulcerative colitis.”

Inflamm Bowel Dis 2005: 11(12): 1085-91
24 November 2005

Go to top of page Email this page Email this page to a colleague

 20 April 2018 
Obesity and physical activity in diverticulosis
 20 April 2018 
Worldwide H.pylori prevalence
 20 April 2018 
Adalimumab with azathioprine in Crohn's
 20 April 2018 
Antibody suitable for further clinical development to complement existing therapeutic strategies for HCV
 19 April 2018 
Fibrosis in patients with chronic hepatitis B
 19 April 2018 
c-Myc expression and pancreatic cancer
 19 April 2018 
Olmesartan prescription in the USA
 18 April 2018 
Online tool predicts bowel dysfunction severity prior to anterior resection
 18 April 2018 
Hep C treatment for sustained virologic response
 18 April 2018 
Endoscopic necrosectomy reduces risk of death 
 17 April 2018 
Colorectal cancer screening and ethnic inequities
 17 April 2018 
Training programs should consider radiation education for advanced endoscopy fellows
 17 April 2018 
Aspirin and pancreatic cancer
 16 April 2018 
Surgery for colorectal polyps has increased 
 16 April 2018 
Advanced fibrosis can be ruled out in primary health care patients
 16 April 2018 
Antibiotic use and colorectal adenoma
 13 April 2018 
Colorectal cancer cell lines
 13 April 2018 
Infliximab and corticosteroid-free clinical remission in Crohn's
 13 April 2018 
Teduglutide for children with short bowel syndrome
 12 April 2018 
Prescriptions for opiate drugs amongst primary care patients with IBD
 12 April 2018 
Lower GI bleeding related to comorbidity
 12 April 2018 
non–Clostridium difficile bacterial infections in IBD
 11 April 2018 
Physician perception of IBD trial results
 11 April 2018 
Bile acid deficiency in IBS 
 11 April 2018 
Stem cell therapy for fistulas in Crohn's
 10 April 2018 
Overweight in childhood and type 2 diabetes
 10 April 2018 
immunoglobulin G associates with clinical features of IBD
 10 April 2018 
T-cells repertoires in celiac disease
 09 April 2018 
Biomarker tests for colorectal cancer screening
 09 April 2018 
Fecal transplantation in C. difficile infection and treatment outcome 
 09 April 2018 
No weigh-loss drug improved all cardiometabolic risk factors
 06 April 2018 
Colonoscopy and colorectal cancer mortality
 06 April 2018 
Eosinophilic esophagitis and health-related quality of life
 06 April 2018 
Microbiome in athletes vs sedentary subjects
 05 April 2018 
Laparoscopic Nissen fundoplication for GERD treatment
 05 April 2018 
Random biopsies for neoplasia in IBD
 05 April 2018 
Scoring system identifies cancer risk in Barrett's
 04 April 2018 
Alpha‐1 antitrypsin deficiency and liver disease
 04 April 2018 
PPI and risk of stroke
 04 April 2018 
Adjuvant chemotherapy for advanced colon cancer
 29 March 2018 
Prevention of metachronous gastric cancer
 29 March 2018 
Acute lower GI bleeding
 28 March 2018 
Decision aid used by IBD patients
 28 March 2018 
Transition for young adults with IBD
 28 March 2018 
Amitriptyline in functional dyspepsia
 27 March 2018 
Emergency department utilization for IBD 
 27 March 2018 
Management of hemorrhoids in the USA
 27 March 2018 
Adult ulcerative colitis
 26 March 2018 
Biological therapy response in IBD 
 26 March 2018 
Obesity and diverticulosis
 26 March 2018 
Practice guidelines for chronic constipation
 23 March 2018 
Health-related quality of life in eosinophilic esophagitis
 23 March 2018 
Genetics and chronic liver disease
 23 March 2018 
Global prevalence of H.pylori
 22 March 2018 
H. pyloris and gastric cancer
 22 March 2018 
Pancreatitis after IBS treatment 
 22 March 2018 
Mechanisms of action in patients with IBS
 21 March 2018 
Panel markers for early detection of colon cancer

 21 March 2018 
Blood test differentiates celiac disease
 21 March 2018 
Patient characteristics and colonoscopy preparation

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us