Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 20 February 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Donor screening should include test for Hep C virus RNA

The latest Annals of Internal Medicine reports transmission of Hep C to several organ and tissue recipients from an antibody-negative donor, and suggests donor screening should include routine testing for Hep C virus RNA.

News image

fiogf49gjkf04

Although Hepatitis C virus transmission through tissue transplantation has been rarely reported, a donor with undetected viremia may infect several recipients.

A patient developed acute Hepatitis C shortly after tissue transplantation.

Dr Barna Tugwell and colleagues conducted a descriptive epidemiologic study and serum testing for Hepatitis C infection.

The investigators determined whether the donor was the source of infection and the extent of transmission to other organ and tissue recipients.

The team recovered 91 tissues or organs from the donor, and assessed the donor and graft recipients located in 16 states and 2 other countries.

Hepatitis C virus infection was defined as the presence of anti-Hepatitis C virus or Hepatitis C virus RNA.

No cases of transmission occurred in recipients of skin or the cornea
Annals of Internal Medicine

The investigative team determined the genetic relatedness of viral isolates from the donor and recipients by genotype comparison and quasi-species analysis.

The team reported that the donor was anti-Hepatitis C virus-negative but was Hepatitis C virus RNA-positive having genotype 1a.

The team noted that 40 persons received transplants during 22 months.

The investigators identified 5 persons who were Hepatitis C-infected before transplantation or had a genotype other than 1a.

A further 5 persons had no post-transplantation serum specimens available.

Of the remaining 30 recipients, the team observed that Hepatitis C infection occurred in 8 recipients.

The infection occurred in 3 of 3 organ recipients, 1 of 2 saphenous vein recipients, 1 of 3 tendon recipients, and 3 of 3 tendon with bone recipients.

These 8 recipients had viral isolates genetically related to those of the donor.

In addition, the investigators observed no cases occurring in 2 recipients of skin, 1 recipient of the cornea, or in 16 receiving irradiated bone.

The team reported that a limitation of the study was that post-transplantation serum specimens were unavailable for 5 recipients.

Dr Tugwell's team commented, “An anti-Hepatitis C-negative donor was the source of Hepatitis C infection for 8 recipients of organs or tissues.”

“Although Hepatitis C transmission from anti-Hepatitis C-negative donors is probably uncommon, changes in donor screening to include routine testing for Hepatitis C virus RNA merit further consideration to improve the safety of transplantation.”

Ann Int Med 2005: 143(9): 648-54
04 November 2005

Go to top of page Email this page Email this page to a colleague

 20 February 2018 
Complications and surveillance colonoscopies
 20 February 2018 
Treatment algorithm for polyp cancers
 20 February 2018 
Predictors of postoperative infection in Crohn's
 19 February 2018 
Screening colonoscopy in the right and left colon
 19 February 2018 
NAFLD prevalence in the USA
 19 February 2018 
Fructans in children with IBS

 16 February 2018 
Undetected celiac in the elderly
 16 February 2018 
Inflammatory bowel diseases are global diseases
 16 February 2018 
Fructans induce non-celiac gluten sensitivity
 15 February 2018 
Oral direct-acting antiviral treatment for Hep C virus genotype 1
 15 February 2018 
NSAIDS and GI damage
 15 February 2018 
Primary vs secondary surgery for the presence of lymph node metastasis
 14 February 2018 
Management of hemorrhoids in the USA
 14 February 2018 
Predicting adenoma detection rate
 14 February 2018 
Normal bowel frequency characterization in the USA 
 13 February 2018 
Prebiotics improve endothelial dysfunction
 13 February 2018 
Personalising treatment options for IBS
 13 February 2018 
Diagnostic criteria for a Rome IV functional gastrointestinal disorders
 12 February 2018 
Visceral hypersensitivity and functional GI disorders
 12 February 2018 
Depression and aggressive IBD
 12 February 2018 
Variability in interpretation of endoscopic findings impacts patient management
 09 February 2018 
Treatment of choice for anastomotic stricture in IBD
 09 February 2018 
PRO measurement information system 
 09 February 2018 
Overall disease severity indices for IBD
 08 February 2018 
Prediction of endoscopically active disease

 08 February 2018 
Steroid-refractory acute severe ulcerative colitis
 08 February 2018 
Decision aid used by IBD patients
 07 February 2018 
Ursodeoxycholic acid combined with bezafibrate for itching
 07 February 2018 
Change in microbiome in gastritis vs gastric carcinoma
 07 February 2018 
Colorectal cancer and primary sclerosing cholangitis-IBD
 06 February 2018 
Risk of death after liver transplantation
 06 February 2018 
Crohn’s disease vs refractory pouchitis
 06 February 2018 
Support for functional dyspepsia symptom diary
 05 February 2018 
Helicobacter spp influence on GI tract 
 05 February 2018 
No link found between severe reflux and all-cause mortality 
 05 February 2018 
Psychological distress in PPI non-responders
 02 February 2018 
Assessing psychosexual impact of IBD
 02 February 2018 
Decrease in overall mortality with cholera vaccination
 02 February 2018 
Diagnostic performance of fecal immunochemical tests
 01 February 2018 
Screening frequency with family histories of colorectal cancer
 01 February 2018 
IBD and sport participation
 01 February 2018 
Life with a stoma 
 31 January 2018 
Aprepitant and gastroparesis 
 31 January 2018 
Anesthesia risk in colonoscopy
 31 January 2018 
GED-0301 for Crohn's Disease
 30 January 2018 
Intestinal dysbiosis and allergic diseases in infants
 30 January 2018 
Fructans and IBS symptoms in children
 29 January 2018 
Dosing calculator for therapy optimization in IBD
 29 January 2018 
Glecaprevir–pibrentasvir for in HCV
 29 January 2018 
Food allergen injections in eosinophilic esophagitis
 29 January 2018 
Reliability of the IBD index
 26 January 2018 
Tofacitinib vs biological therapies for ulcerative colitis
 26 January 2018 
Optimizing selection of biologics in IBD
 26 January 2018 
Nutritional risk and laparoscopic-assisted gastrectomy outcomes
 25 January 2018 
Patient-reported outcome measure for functional dyspepsia
 25 January 2018 
Predicting intra-abdominal infections after colorectal surgery
 25 January 2018 
Predictors of gastric cancer risk
 24 January 2018 
Risk factors underlying previously undiagnosed cirrhosis
 24 January 2018 
Ethnicity influences phenotype in IBD
 24 January 2018 
Bariatric surgery vs medical obesity treatment

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us