Recent reports suggest that Helicobacter pylori infection can potentially increase the risk of colorectal cancer.
Dr Shunji Fujimori and colleagues from Japan assessed the association between H pylori and colorectal adenoma and adenocarcinoma risk.
The researchers evaluated any differences on the basis of sex.
The subjects were 669 patients who underwent both barium enema examination and total colonoscopy.
The research team evaluated the patients for H pylori infection by 13C-urea breath test, and urease test.
|H pylori infection significantly increased odds ratio for adenoma|
|Journal of Gastroenterology|
The team also evaluated histological diagnosis of biopsied gastric specimens.
There were 142 H pylori-negative and 527-positive patients.
The team measured odds ratios for H pylori-positive patients with colorectal adenoma and adenocarcinoma.
In addition, tumor patients with either adenoma or adenocarcinoma were calculated.
Among the H pylori-negative patients, there were 52 patients without tumor, 63 with adenoma, 27 with adenocarcinoma, and 90 with tumor.
The team found that among the H pylori-positive patients, there were 136, 264, 127, and 391 patients respectively.
Pooling all subjects, the researchers noted that those infected with H pylori had a significantly increased odds ratio for adenoma.
Those infected with H pylori had a significantly increased odds ratio for adenocarcinoma, or tumor, compared to H pylori-free patients.
The researchers observed that for female H pylori-positive subjects, the risk of having adenocarcinoma or tumor was significantly higher.
The research team found that for male H pylori-positive and -negative subjects, there was no such significant difference.
Dr Fujimori's concludes, “The results therefore suggest that, in patients aged 40 to 80 years, H pylori infection increased the risk of colorectal adenoma and adenocarcinoma, with significantly higher risks for female patients.”