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News

Colonic neoplasia not influenced by age or gender

Data in the latest Journal of Clinical Gastroenterology show similar rates of neoplasia recurrence among patients of different gender and age groups on surveillance colonoscopy.

News image

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Current guidelines endorse surveillance colonoscopy at 3 to 5 years following initial detection of neoplasia.

However, individual patients' risks may vary according to age and gender.

Dr Gavin Harewood and colleague characterized neoplasia recurrence in a large patient cohort undergoing surveillance colonoscopy.

All patients undergoing 2 colonoscopies at least 12 months apart between 1996 and 2000 were included.

The patients had detection and removal of a polyp on the index colonoscopy.

The investigative team identified the patients using their endoscopic database to determine the incidence of colonic neoplasia.

Patients were classified according to age categories of less than 50, 50 to 64, 65 to 74, and 75 or more years.

Polyps of 5 mm or more were detected in 19% of patients
Journal of Clinical Gastroenterology

Anaesthesia was induced with vecuronium 0.1 mg kg-1 and propofol 2 mg kg-1.

The team also categorized the patients according to gender.

Overall, 1803 patients underwent 2 colonoscopies at least 12 months apart with removal of a polyp on initial examination.

The team detected polyps of 5 mm or more in 19% of patients.

Polyps 10 mm or more were found in 6% on subsequent endoscopy.

The investigators reported that all age and gender groups were well matched with respect to size of polyp detected on initial colonoscopy.

Kaplan-Meier curves and a Cox proportional hazards model demonstrated similar rates of neoplasia recurrence for all patients irrespective of age and gender.

Dr Harewood's team concludes, “Similar rates of neoplasia recurrence were observed among patients of different gender and age groups on surveillance colonoscopy.”

“From a health resource utilization perspective, these findings support current recommendations for similar surveillance intervals for patients regardless of age and gender.”

J Clin Gastroenterol 2005: 39(10): 894-99
13 October 2005

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