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 19 January 2018

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News

Rofecoxib does not inhibit human gastric mucosal prostaglandin production

Rofexicob, unlike naproxen, does not reduce the availability of gastro-protective prostaglandins, according to research reported in March's Gastroenterology.

News image

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A team from Nottingham, England, and Rahway, New Jersey, investigated whether rofexicob, a COX-2 inhibitor, hinders the synthesis of gastric mucosal prostaglandin.

Effect of treatment on synthesis of gastric mucosal prostaglandin:
Naproxen: decrease of 65%
Rofexicob: increase of 18%
Gastroenterology

24 healthy, non-smoking Helicobacter pylori-negative volunteers were randomized to one of two separate concurrent blinded crossover studies.

16 volunteers received rofecoxib, 50 mg once daily, for 5 days in one treatment period and placebo in the other.

8 volunteers similarly received naproxen, 500 mg twice daily, and placebo.

On Day 5 of each period, antral mucosal prostaglandin E2 (PGE2) synthesis was measured by radioimmunoassay after vortexing for 3 minutes. Whole blood COX-1 activity was measured as serum thromboxane (TXB)2- and COX-2 activity as lipopolysaccharide (LPS)-induced PGE2.

The team found that, compared to placebo, naproxen decreased gastric mucosal PGE2 synthesis by 65% in contrast to an 18% increase after rofecoxib.

Naproxen also significantly inhibited both serum TXB2 by 94% and LPS-induced PGE2 production by 77%, but rofecoxib only inhibited COX-2-dependent LPS-induced PGE2 (by 79%).

Nicholas Wight, of the University Hospital, Nottingham, concluded on behalf of the group, "Rofecoxib (50 mg) lacked naproxen's ability to reduce the availability of gastro-protective prostaglandins."

Gastroenterology 2001; 120: 867-73
12 March 2001

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