Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 24 November 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Mesalazine combination therapy in IBD

Mesalazine has synergistic effects on mercaptopurine therapy, and combining these drugs may be further indication for mesalazine in inflammatory bowel disease treatment, shows October's Alimentary Pharmacology & Therapeutics.

News image

fiogf49gjkf04

In vitro studies suggest interactions between mesalazine and thiopurines by thiopurine S-methyltransferase inhibition.

These influence the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive tioguanine metabolites.

Dr Gilissen and colleagues examined the in vivo pharmacokinetic interaction between mesalazine and mercaptopurine.

The researchers performed a prospective study in quiescent inflammatory bowel disease patients.

The research team used the combination of mercaptopurine and mesalazine.

Laboratory parameters, 6-methylmercaptopurine ribonucleotide and tioguanine levels were measured.

The team also measured thiopurine S-methyltransferase activity in erythrocyes at stable medication.

6-methylmercaptopurine ribonucleotide/tioguanine ratio increased from 6 to 11
Alimentary Pharmacology & Therapeutics

After mesalazine discontinuation and mesalazine reintroduction, further mercaptopurine was continued.

The team reported that 17 patients participated.

The mean mercaptopurine dose was 0.8 mg/kg/day and median of mesalazine dose was 3000 mg/day.

After mesalazine discontinuation, tioguanine levels changed from 262 to 209 pmol/8x108 red blood cell, increasing to 270 after reintroduction.

The researchers found that mean 6-methylmercaptopurine ribonucleotide levels were 1422, 2149 and 1503 pmol/8x108 red blood cell respectively.

Mean 6-methylmercaptopurine ribonucleotide/tioguanine ratio increased significantly from 6 at baseline to 11.

The team noted that mean baseline thiopurine S-methyltransferase activity was 0.6 pmol/106 red blood cell/h and stable.

The researchers found that all patients had wild-type thiopurine S-methyltransferase genotypes however, leucocyte counts were stable.

A higher tioguanine levels and improving 6-methylmercaptopurine ribonucleotide/tioguanine ratio were found during mesalazine/mercaptopurine combination.

Theoretically, mesalazine inhibits thiopurine S-methyltransferase activity.

However, the team observed that in vivo thiopurine S-methyltransferase activity did not change.

Dr Gilissen's team concludes, “Mesalazine has synergistic effects on mercaptopurine therapy, but the mechanism is unclear.”

“Combining these drugs may be further indication for mesalazine in inflammatory bowel disease treatment.”

Aliment Pharmacol Ther 2005: 22(7): 605
20 March 2005

Go to top of page Email this page Email this page to a colleague

 24 November 2017 
Osteoporotic fractures in Barrett's esophagus
 24 November 2017 
Center ERCP volume and procedure success
 24 November 2017 
Adipokines and IBD
 23 November 2017 
Pharmacological management of GERD
 23 November 2017 
Incidence of biopsy-verified celiac disease
 23 November 2017 
Distance travelling for rectal cancer outcomes
 22 November 2017 
Challenges of US-trained gastroenterologists when abroad
 22 November 2017 
Surgical treatment delays influence survival in colon cancer
 22 November 2017 
Golimumab in Crohn's disease
 21 November 2017 
Preoperative optimization in IBD patients
 21 November 2017 
Cholangiopathy in critically ill patients
 21 November 2017 
Prepregnancy obesity and maternal mortality
 20 November 2017 
Barriers to hepatitis C treatment
 20 November 2017 
Socioeconomic characteristics in diverticular disease
 20 November 2017 
Endoscopic indices of disease activity for Crohn’s
 17 November 2017 
Food elimination diets for treatment of adults with eosinophilic esophagitis
 17 November 2017 
PPI use and cognitive function in women
 17 November 2017 
Predicting microscopic colitis
 16 November 2017 
NAFLD-hepatocellular carcinoma and survival after orthotopic liver transplant
 16 November 2017 
Prepregnancy obesity and severe maternal morbidity
 16 November 2017 
Celiac disease screening in adult first-degree relatives
 15 November 2017 
Breastfeeding and the risk of IBD
 15 November 2017 
Predicting recurrence after curative rectal cancer surgery
 15 November 2017 
Medication nonadherence and health care costs
 14 November 2017 
Eosinophilic gastroenteritis and colitis
 14 November 2017 
HBV/HCV coinfection and cirrhosis
 14 November 2017 
Sexual dysfunction after rectal cancer surgery
 13 November 2017 
Genetic polymorphisms, fatty acids and ulcerative colitis
 13 November 2017 
Flares after immunomodulator withdrawal in Crohn's
 13 November 2017 
GI bleeding in patients taking non–vitamin K antagonist oral anticoagulants
 10 November 2017 
Thiopurines vs TNF and lymphoma risk in IBD
 10 November 2017 
Drug monitoring of anti-tumour necrosis factor therapy in IBD
 10 November 2017 
Treatment decisions for older patients with colorectal cancer
 09 November 2017 
Quality standards in upper gastrointestinal endoscopy
 09 November 2017 
Irradiated rectal cancer and chemoradiotherapy
 09 November 2017 
Environmental factors and IBD
 08 November 2017 
Prophylaxis of spontaneous bacterial peritonitis
 08 November 2017 
Optimal management of postoperative Crohn's disease
 07 November 2017 
Community Screening for Helicobacter pylori
 07 November 2017 
Early readmission in IBD patients
 07 November 2017 
Mesocolic excision for colon cancer
 06 November 2017 
Food elimination diet for children with eosinophilic esophagitis
 06 November 2017 
Biologic agents and obesity in children with IBD
 06 November 2017 
Liver cancer burden despite extensive use of antiviral agents
 03 November 2017 
Statins and mortality in chronic viral hepatitis
 03 November 2017 
Propofol for outpatient colonoscopy
 03 November 2017 
Asthma and IBD development
 02 November 2017 
Diverticulitis and emergency department burden
 02 November 2017 
Rural residence and risk of IBD
 02 November 2017 
Sexual functioning in Hep C
 01 November 2017 
Autoimmune pancreatitis in children
 01 November 2017 
Heartburn relief in adolescents with GERD
 31 October 2017 
Follow-up of positive results on fecal blood tests
 31 October 2017 
Surveillance in ulcerative colitis and Crohn’s disease
 30 October 2017 
Local recurrence after curative rectal cancer surgery
 30 October 2017 
Low-flow ascites pump in refractory cirrhosis
 30 October 2017 
Medical therapy of patients with pediatric-onset IBD
 27 October 2017 
NAFLD in advanced fibrosis in the USA
 27 October 2017 
Early readmission in cirrhosis after bacterial infections
 26 October 2017 
Predicting response to anti-TNF therapy in Crohn's

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us