Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 22 May 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Abdominal obesity increases Barrett's esophagus risk

Obesity seems to be associated with an increased risk of Barrett's esophagus, and abdominal visceral adiposity might mediate most of this risk, finds the latest issue of the American Journal of Gastroenterology.

News image

fiogf49gjkf04

The association between overweight/obesity and the risk of Barrett's esophagus is unclear.

Further, the association between body fat distribution and the risk of Barrett's esophagus is unknown.

Dr El-Serag and colleagues from Texas conducted a retrospective case-control study in patients who underwent endoscopy.

The patients were treated at a single large VA Medical Center between 2000 and 2003.

The patients included in the study had documented Barrett's esophagus who had an abdominal CT scan within 1 yr of the endoscopy.

The controls were patients without Barrett's esophagus, with or without erosive esophagitis, who also had an abdominal CT scan.

The surface areas of visceral adipose tissue and subcutaneous adipose tissue were calculated from CT scan images at level of intervertebral disc between L4 and L5.

The research team recorded body mass index in kg/m2 at the time of endoscopy.

Cases and controls were compared in univariate and multivariable analyses.

The researchers identified 36 cases and 93 controls.

Visceral adipose tissue was approximately 2-fold greater in cases than controls
American Journal of Gastroenterology

The team found no significant differences between cases and controls in age, gender, or race.

The mean age of the cases and controls was 63 years, of which 98% were men and 71% were white Caucasian.

The researchers observed that body mass index was significantly greater in cases than controls.

Body mass index greater than 30 kg/m2 was associated with a greater risk of Barrett's esophagus than lower body mass index.

Visceral adipose tissue was approximately 2-fold greater in cases than controls, whereas subcutaneous adipose was less different.

The research team estimated that each 10-cm2 increase in visceral adipose tissue was associated with 9% increase in risk of Barrett's esophagus.

Interestingly, visceral adipose tissue remained independently associated with Barrett's esophagus in the model that adjusted for body mass index.

In that model, the team noted that body mass index was not significantly associated with Barrett's esophagus.

Dr El-Serag's team concluded, “Obesity seems to be associated with an increased risk of Barrett's esophagus.”

“Abdominal visceral adiposity might mediate most of this risk.”

Am J Gastroenterol 2005: 100(10): 2151
27 September 2005

Go to top of page Email this page Email this page to a colleague

 22 May 2018 
Worldwide H.pylori prevalence
 22 May 2018 
PPI and risk of stroke
 22 May 2018 
Online tool predicts bowel dysfunction severity prior to anterior resection
 21 May 2018 
Fecal incontinence and quality of life in IBD
 21 May 2018 
PPI use and cognitive decline
 21 May 2018 
Depressive symptoms in IBD youth
 18 May 2018 
Esophageal dilatation in clinical practice 
 17 May 2018 
IBD and later extraintestinal manifestations
 17 May 2018 
Repeat stool DNA testing
 17 May 2018 
IBS and chronic fatigue following GI infection
 16 May 2018 
Factors associated with fecal incontinence
 16 May 2018 
Diagnostic delay in Crohn's disease
 16 May 2018 
Cardiovascular risk in diabetes mellitus with NAFLD
 15 May 2018 
Guidelines for management of Crohn's
 15 May 2018 
New therapies for CDI
 15 May 2018 
Hep B in the Grey Zone
 14 May 2018 
Blood test for the diagnosis of fibrotic NASH
 14 May 2018 
Outcomes at bariatric centers of excellence
 14 May 2018 
Management of perianal fistulas in Crohn’s
 11 May 2018 
Detection of undiagnosed celiac disease
 11 May 2018 
Alcohol consumption and drug-induced liver injury
 10 May 2018 
Post‐operative complications in elderly IBD
 10 May 2018 
Colorectal cancer screening
 10 May 2018 
Fibrosis in patients with chronic hepatitis B
 09 May 2018 
Fecal incontinence
 09 May 2018 
Health problems and IBS
 09 May 2018 
Esophageal dilatation in clinical practice 
 07 May 2018 
Omitting antibiotics in uncomplicated acute diverticulitis
 07 May 2018 
Health problems and IBS
 07 May 2018 
Assessment of diminutive colorectal polyps
 04 May 2018 
Factors associated with fecal incontinence
 04 May 2018 
National Institutes of Health workshop and obesity
 04 May 2018 
Colorectal cancer screening and ethnic inequities
 03 May 2018 
Gastrointestinal ultrasound in IBD
 03 May 2018 
Ultransonography in postsurgical recurrence in Crohn's
 02 May 2018 
Symptom assessment in cirrhotic ascites
 02 May 2018 
Hep C antiviral treatment and liver cancer risk
 02 May 2018 
Chronic Hep B
 01 May 2018 
European guidelines on pancreatic cystic neoplasms
 01 May 2018 
Interferon‐free regimens in Hep C
 01 May 2018 
Age at IBD onset and extraintestinal complications
 30 April 2018 
Formula for preterm infants
 30 April 2018 
Primary antibiotic resistance and sequential therapy for H. pylori
 30 April 2018 
Patient-reported outcome measures in IBD trials
 27 April 2018 
Anxiety scale for chronic esophageal disease
 27 April 2018 
Disease activity in eosinophilic esophagitis
 27 April 2018 
Eastern and western practices for endoscopic resection of colorectal lesions
 26 April 2018 
Obesity and physical activity in diverticulosis
 26 April 2018 
Primary sclerosing cholangitis in the USA
 25 April 2018 
Aspirin and pancreatic cancer
 25 April 2018 
Central mediators of irinotecan-induced steatohepatitis
 25 April 2018 
Neuroimaging in Hep C
 24 April 2018 
Scoring system identifies cancer risk in Barrett's
 24 April 2018 
Microbiome in athletes vs sedentary subjects
 23 April 2018 
Genome-wide study on HBV-related acute-on-chronic liver failure
 23 April 2018 
Antibody suitable for further clinical development to complement existing therapeutic strategies for HCV
 23 April 2018 
Sleep deprivation and NAFLD in the USA
 20 April 2018 
Two annexin A11 epitopes targeted by IgG1 and IgG4 autoantibodies were shared between patients with IAC/AIP and IgG4 antibodies blocked binding of IgG1 antibodies to the shared annexin A11 epitopes
 20 April 2018 
Adalimumab with azathioprine in Crohn's
 19 April 2018 
c-Myc expression and pancreatic cancer

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us