Ghrelin stimulates growth hormone and has orexigenic and adipogenic effects.
Plasma ghrelin levels are reduced in obesity and possibly in Helicobacter pylori infection.
Dr Akiko Shiotani and colleagues from Japan investigated a relation between H pylori, body mass index and serum ghrelin or leptin levels.
University students undergoing an annual health check-up were invited to participate.
The investigators based H pylori status on the presence of specific IgG H pylori antibodies in urine.
|LDL-cholesterol levels were higher in the H pylori-positive group|
Fasting serum ghrelin, leptin levels, and pepsinogen I and II levels were measured by enzyme immunoassay.
The investigative team reported that 801 students volunteered.
The team found no significant difference in the height and body mass index between those with and without H pylori infection.
The ghrelin study group consisted of 132 students, of which 66 were H pylori-positive and 66 were H pylori-negative.
The participating students were matched for age, sex, and body mass index.
The investigators noted that the ghrelin level in the H pylori-positive group was significantly lower compared to the H pylori-negative group.
Leptin, triglyceride, total cholesterol, and HDL-cholesterol were not different between the 2 groups.
The investigative team noted that LDL-cholesterol levels were significantly higher in the H pylori-positive group.
The investigators observed that the leptin levels correlated with body mass index.
Among H pylori-positive subjects, ghrelin correlated only with pepsinogen I levels.
Dr Shiotani's team concludes, “H pylori infection was associated with a reduction in circulating ghrelin levels independent of sex and body mass index.