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 25 June 2018

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News

Eradication test advised in H pylori-associated ulcer bleed

Patients with H pylori-associated peptic ulcer bleeding should be tested to confirm eradiation of H pylori after completion of antibiotic treatment, reports this month's Alimentary Pharmacology & Therapeutics.

News image

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Eradication of Helicobacter pylori after peptic ulcer hemorrhage reduces the risk of recurrence.

Although H pylori treatment is very effective, it is unclear whether testing to confirm eradication is worthwhile.

Dr Pohl and colleagues examined if H pylori-associated peptic ulcer hemorrhage should be tested for eradication after completion of antibiotic therapy.

A Markov cost-effectiveness model was developed to compare testing vs non-testing of H pylori eradication in peptic ulcer hemorrhage.

H pylori eradication test cost $836 less than the strategy used not confirming eradication
Alimentary Pharmacology & Therapeutics

The researchers derived probability estimates and average costs from published information.

The research team found that testing for H pylori eradication resulted in a benefit of 0.07 quality-adjusted life-years.

In addition, the researchers found that testing for H pylori eradication cost $836 less than the strategy of not confirming eradication.

Testing remained the superior strategy when varying the model regarding age, the initial success of eradication.

The team noted that testing was better than various test and retreatment strategies, and when varying the model according to the rate and costs of recurrent bleeding.

Assuming an eradication rate of 95%, the test strategy becomes more expensive only if the cost of H pylori testing reaches $265.

However, the researchers observed that even under these conditions it remains cost-effective.

Dr Pohl's team concluded, “Patients with H pylori-associated peptic ulcer bleeding should be tested to confirm eradication of H pylori after completion of antibiotic treatment.

Aliment Pharmacol &Ther 2005: 22(6): 529
15 September 2005

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