Earlier studies indicate a protective effect of smoking against celiac disease, but have been based on small numbers and retrospective collection of smoking data.
Dr Ludvigsson and colleagues studied the association between smoking status during pregnancy and celiac disease in women who were pregnant.
The researchers linked the Swedish national inpatient register and the medical birth register using data from 1983 to 2001.
The research team adjusted for civil status, age, and year when smoking data were collected.
|27% of smokers had undiagnosed celiac disease vs 21% of nonsmokers|
|Clinical Gastroenterology & Hepatology|
The team identified 873 cases of celiac disease, of which 636 were diagnosed and 237 were undiagnosed.
Of 249,967 smokers, 27% had undiagnosed celiac disease vs 21% of non-smokers.
Point estimates remained unchanged when adjusting for civil status, age, and year of smoking data collection.
The team found no associations between smoking and future celiac disease undiagnosed at delivery when adjusted for potential confounders.
The team also found no association between smoking and future celiac disease when stratifying for co-morbidity or time to diagnosis after infant birth.
In women with diagnosed celiac disease, the researchers observed smoking was more common than in women who never had a diagnosis of celiac disease.
Dr Ludvigsson's team concludes, “Smoking seems to have little effect on the risk for future celiac disease in pregnant women.”