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 24 November 2017

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News

Probiotics and relapse in pediatric Crohn's

A study in the latest Inflammatory Bowel Diseases suggests that Lactobacillus rhamnosus strain GG does not prolong time to relapse in children with Crohn's disease when given as an adjunct to standard therapy.

News image

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Probiotics are widely used by patients with Crohn's disease in an attempt to improve their health.

Few controlled studies have been done to evaluate the efficacy of these therapies.

Dr Athos Bousvaros conducted a randomized, placebo-controlled trial of the probiotic Lactobacillus rhamnosus strain GG.

The research team assessed whether the addition of Lactobacillus rhamnosus strain GG to standard therapy prolonged remission in children with Crohn's.

Concomitant medications allowed in the study included aminosalicylates, 6-mercaptopurine, azathioprine, and low-dose alternate day corticosteroids.

The team randomized 75 children aged 5 to 21 years with Crohn's in remission.

The researchers randomized 39 to either Lactobacillus rhamnosus strain GG or 36 to placebo and followed for up to 2 years.

31% of patients in the Lactobacillus rhamnosus strain GG group developed a relapse
Inflammatory Bowel Disease

The team found that median time to relapse was 10 months in the Lactobacillus rhamnosus strain GG group.

Median time to relapse was 11 months in the placebo group.

The researchers noted that 31% of patients in the Lactobacillus rhamnosus strain GG group developed a relapse compared with 17% with placebo.

The research team observed that Lactobacillus rhamnosus strain GG was well tolerated, with a side effect profile comparable with placebo.

Dr Bousvaros' team commented, “This study suggests that Lactobacillus rhamnosus strain GG does not prolong time to relapse in children with Crohn's disease when given as an adjunct to standard therapy.”

Inflamm Bowel Dis 2005: 11(9): 833-9
25 August 2005

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