The benefits of serologic screening for celiac disease in asymptomatic individuals are debatable.
Dr Kaukinen and colleagues from Finland investigated dietary compliance, quality of life and bone mineral density after long-term treatment in celiac patients screened as risk groups.
The study comprised 53 consecutive screen-detected celiac patients diagnosed 14 years ago.
The researchers assessed dietary compliance by interview, 4-day food record and serology.
Quality of life was evaluated by the Psychological General Well-Being and SF-36 questionnaires.
|96% of screen-detected celiac patients adhered to a gluten-free diet|
|Alimentary Pharmacology & Therapeutics|
The team also assessed gastrointestinal symptoms using the Gastrointestinal Symptom Rating Scale.
Bone mineral density was assessed by dual-energy x-ray absorptiometry.
The research team made comparisons to 44 symptom-detected-treated celiac patients, 110 non-celiac subjects and the general population.
The team detected a total of 96% of screen-detected and 93% of symptom-detected celiac patients adhered to a strict or fairly strict gluten-free diet.
In screen-detected patients, the team noted that quality of life and gastrointestinal symptoms were similar to those in symptom-detected patients or non-celiac controls.
The researchers also observed that bone mineral density was similar to that in the general population.
Dr Kaukinen's team concludes, “Long-term dietary compliance in screen-detected patients was good.”
“Quality of life and bone mineral density were comparable with those in non-celiac subjects and the general population.”
Active screening in celiac disease risk groups seems to be reasonable rather than harmful.”