It has been reported that some patients develop functional digestive disorders, particularly irritable bowel syndrome (IBS), after acute gastroenteritis.
However, the presence of dyspepsia has not been specifically addressed.
Dr Fermín Mearin and colleagues prospectively evaluated the development of dyspepsia and IBS during a 1-year follow-up in a cohort of adult patients.
The patients were affected by a Salmonella enteritidis acute gastroenteritis outbreak.
The researchers sent out questionnaires to 1878 potential participants at baseline and 3, 6, and 12 months.
The team found that 677 had experienced a Salmonella enteritidis acute gastroenteritis in 2002.
The researchers randomly selected 1201 controls without Salmonella enteritidis acute gastroenteritis, matched for village of residence, age, and sex.
|Prolonged abdominal pain during acute gastroenteritis is a predictor of dyspepsia|
At 12 months, 271 patients and 335 controls returned the questionnaires.
The researchers establishment dyspepsia and IBS diagnosis by Rome II criteria.
The team found that within the acute gastroenteritis outbreak, the prevalence of dyspepsia was similar in cases and controls.
The researchers also noted that the prevalence of IBS was similar between the groups.
At 3, 6, and 12 months, the prevalence of both dyspepsia and IBS had increased significantly in exposed compared with unexposed subjects.
The team noted that overlap between dyspepsia and IBS was frequent and at 1 year, the relative risk for development of dyspepsia was 5 and for it was IBS was 7.
Prolonged abdominal pain and vomiting during acute gastroenteritis were positive predictors of dyspepsia.
In addition, the team reported that no predictive factors for IBS were found.
Dr Mearin's team concludes, “Salmonella gastroenteritis is a significant risk factor not only for IBS but also for dyspepsia.”
“At 1 year of follow-up, 1 in 7 and 1 in 10 subjects developed dyspepsia or IBS, respectively.”